Predictive value of transforming growth factor-β1,cytokeratin 19,and neutrophil-to-lymphocyte ratio for the prognosis of patients with advanced liver cancer undergoing intensity-modulated radiotherapy
Objective To analyze the predictive value of single and combined detection of transforming growth fac-tor-β1(TGF-β1),cytokeratin 19(CK19),and neutrophil-to-lymphocyte ratio(NLR)for the prognosis of patients with ad-vanced liver cancer undergoing intensity-modulated radiotherapy(IMRT).Method A total of 72 patients with advanced liver cancer who received IMRT were selected,and followed up for 4 months after the treatment,the prognosis was re-corded,and the levels of TGF-β1,CK19,and NLR in advanced liver cancer patients underwent IMRT with different prog-nosis were compared.The receiver operating characteristic(ROC)curve was draw,the area under the curve(AUC)was calculated,and the predictive value of TGF-β1,CK19,and NLR single and combined detection for the prognosis of ad-vanced liver cancer patients undergoing IMRT were evaluated.Result After 4 months followed up,43 cases had a good prognosis,29 cases had a poor prognosis among the 72 patients with liver cancer undergoing IMRT.After radiotherapy,the levels of TGF-β1,CK19,and NLR in patients with poor prognosis were higher than those in patients with good prog-nosis,and the differences were statistically significant(P＜0.01).The ROC curve showed that,the AUC of TGF-β1,CK19,and NLR combined detection to predicted the prognosis of advanced liver cancer patients underwent IMRT was 0.894(95％CI:0.799-0.954),which was higher than the single detection of each indicator,the sensitivity was 79.31％,and the specificity was 93.02％.Conclusion The combined detection of TGF-β1,CK19,and NLR has a good value in predicting the prognosis of advanced liver cancer patients underwent IMRT.
万方数据
维普
