Relationship between four items of serum gastric function,helicobacter pylori and early gastric cancer
Objective To explore the relationship between four items of serum gastric function[pepsinogen(PG)Ⅰ,PGⅡ,PGⅠ/PGⅡ(PGR),gastrin-17(G-17)],helicobacter pylori and early gastric cancer.Method A total of 82 people screened for gastric cancer were divided into early cancer group(n=20)and benign group(n=62)according to the results of gastroscopy and pathological examination.The clinical characteristics of the two groups were compared.The influenc-ing factors of occurrence of early gastric cancer were analyzed by Logistic regression analysis.The diagnostic value of PGⅡ,G-17,PGI,PGR single and combined detection for early gastric cancer was analyzed by receiver operating charac-teristic(ROC)curve and area under the curve(AUC).Result The age,helicobacter pylori antibody,family history of gastric cancer,smoking history,PGⅠ,PGⅡ,PGR,and G-17 of the two groups were compared,and the differences were statistically significant(P＜0.05).Logistic regression analysis showed that age,helicobacter pylori antibody,family histo-ry of gastric cancer,smoking history,PGⅠ,PGⅡ,PGR and G-17 were influencing factors of the occurrence of early gas-tric cancer(P＜0.05).ROC curve showed that the AUC of PGⅠ,PGⅡ,PGR,and G-17 combined detection in diagnosis of early gastric cancer were higher than those of each indicators single detection.Conclusion Age,helicobacter pylori anti-body,family history of gastric cancer,smoking history,PGⅠ,PGⅡ,PGR,G-17 were the influencing factors of the occur-rence of early gastric cancer.The combined detection of PGⅠ,PGⅡ,PGR and G-17 has high diagnostic value for early gas-tric cancer.
gastric cancerfour items of gastric functionhelicobacter pyloridiagnosis
万方数据
维普
