Predictive value of Toll like receptor 4,procalcitonin,and high mobility group protein B1 in children with intracranial tumor complicated with postoperative severe pneumonia
Objective To investigate the predictive value of Toll like receptor 4(TLR4),procalcitonin(PCT)and high mobility group protein B1(HMGB1)in children with intracranial tumor complicated with postoperative severe pneu-monia.Method A total of 65 children with intracranial tumor were divided into observation group(n=30,complicated with severe pneumonia)and control group(n=35,not complicated with severe pneumonia)according to whether severe pneumonia occurred after resection of intracranial tumor.The clinical data of the two groups were collected,and the influ-encing factors of postoperative severe pneumonia in children with intracranial tumor were analyzed by Logistic regres-sion model.The receiver operating characteristic(ROC)curve was plotted and the area under the curve(AUC)was calcu-lated to analyze the predictive value of TLR4,PCT and HMGB1 for postoperative severe pneumonia in children with in-tracranial tumor.Result Univariate analysis showed that the proportion of patients with preoperative Glasgow coma scale(GCS)score＜8 points,drainage tube retention time≥3 days,intensive care unit(ICU)stay time≥ 7 days and TLR4,PCT and HMGB1 levels in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that preoperative GCS score＜8 points,drainage tube retention time≥3 days,ICU stay time≥7 days,and TLR4,PCT,HMGB1 increased were independent risk factors for postoperative severe pneumonia in children with intracranial tumor(P＜0.05).ROC curve showed that the AUC of TLR4,PCT and HMGB1 in predicting postoperative severe pneumonia in children with intracranial tumor were 0.838,0.955 and 0.827,respectively.Conclusion TLR4,PCT and HMGB1 can be used as important indicators to pre-dict postoperative severe pneumonia in children with intracranial tumor.
Toll like receptor 4procalcitoninhigh mobility group protein B1intracranial tumorsevere pneumonia
万方数据
维普
