Effect of laparoscopic surgery on tumor markers,coagulation function and immune function in patients with endometrial cancer
Objective To investigate the effect of laparoscopic surgery on tumor markers,coagulation function and immune function in patients with endometrial cancer.Method A total of 87 patients with endometrial cancer were divid-ed into open group(n=43,open surgery)and laparoscopic group(n=44,laparoscopic surgery)according to different surgi-cal methods.The perioperative indicators,serum tumor markers[carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),human epididymis protein 4(HE4)],coagulation function indicators[prothrombin time(PT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)],immune function indicators(CD3+,CD4+,CD8+,CD4+/CD8+)and the incidence of complications were compared between the two groups.Result The operation time,first postopera-tive exhaust time,first postoperative getting out of bed time,catheterization time and hospital stay in laparoscopic group were significantly shorter than those in open group,and the intraoperative blood loss was significantly less than that in open group,and the differences were statistically significant(P＜0.01).Three days after surgery,the serum CA125,HE4 and CEA levels in both groups were lower than those before surgery,and the serum CA125,HE4 and CEA levels in lapa-roscopic group were lower than those in open group,and the differences were statistically significant(P＜0.05).Three days after surgery,the PT and APTT in both groups were shorter than those before surgery,and the FIB levels were high-er than those before surgery,the PT and APTT in laparoscopic group were shorter than those in open group,and the FIB level was higher than that in open group,and the differences were statistically significant(P＜0.05).Three days after sur-gery,the levels of CD3+,CD4+and CD4+/CD8+in both groups were lower than those before surgery,and the levels of CD8+were higher than those before surgery,and the levels of CD3+,CD4+and CD4+/CD8+in laparoscopic group were higher than those in open group,and the level of CD8+was lower than that in open group,and the differences were statisti-cally significant(P＜0.05).The total incidence of complications in laparoscopic group was lower than that in open group(P＜0.05).Conclusion In the treatment of patients with endometrial cancer,laparoscopic surgery can reduce the amount of intraoperative blood loss,shorten the operation time,reduce the levels of serum tumor markers and the impact on im-mune function,promote postoperative recovery,and have high safety,but it is easy to have adverse effects on coagulation function,and corresponding measures should be taken clinically.
endometrial cancerlaparoscopic surgeryopen surgerytumor markercoagulation functionimmune function
万方数据
维普
