Application effect of immunotherapy combined with anti-angiogenic therapy in patients with advanced non-small cell lung cancer
Objective To explore the application effect of immunotherapy combined with anti-angiogenic therapy in patients with advanced non-small cell lung cancer(NSCLC).Method According to different treatment methods,82 pa-tients with advanced NSCLC were divided into observation group(n=49)and control group(n=33).Both groups were given chemotherapy,the control group received anti-angiogenic drug bevacizumab therapy,and the observation group re-ceived camrelizumab combined with bevacizumab therapy.The clinical efficacy,T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+),inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],quality of life[Karnofsky per-formance status(KPS)score],and incidence of adverse reactions were compared between two groups.Result The objec-tive response rate of the observation group was 34.69%,which was higher than 12.12%of the control group(P<0.05),and the disease control rate was 87.76%,which was higher than 66.67%of the control group(P<0.05).After treatment,the levels of CD3+,CD4+,and CD4+/CD8+ in both groups were higher than those before treatment,the levels of CD3+,CD4+,and CD4+/CD8+ in the observation group were higher than those in the control group,and the differences were sta-tistically significant(P<0.05).After treatment,the levels of TNF-α and IL-6 in both groups were lower than those before treatment,and the KPS scores were higher than those before treatment,the levels of TNF-α and IL-6 in the observation group were lower than those in the control group,and the KPS score was higher than that in the control group,the differ-ences were statistically significanant(P<0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Immunotherapy combined with anti-angiogenesis therapy has a good ef-fect in the treatment of advanced NSCLC,which can improve immune function,reduce inflammation,improve quality of life,and is relatively safe.
NETL
NSTL
万方数据
维普
