Analysis of influencing factors on venous thromboembolism in patients with non-small cell lung cancer under immunotherapy
Objective To analyze the influencing factors on venous thromboembolism(VTE)in patients with non-small cell lung cancer(NSCLC)under immunotherapy.Method A total of 62 patients under immunotherapy were select-ed,and their general information,blood lipid indicators[triglyceride(TG),total cholesterol(TC)],and coagulation func-tion indicators[thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-dimer(D-D),and platelet]were collected.The influencing factors of VTE occurrence in NSCLC immunothera-py patients were analyzed by multivariate Logistic regression.Result Among 62 NSCLC patients,36 cases had VTE and 26 cases did not.Univariate analysis showed that pathological type may not be influencing factor for VTE occurrence in NSCLC immunotherapy patients(P>0.05).Gender,age,merge underlying diseases,clinical staging,smoking history,alcohol consumption history,blood type O,body mass index(BMI),Eastern Cooperative Oncology Group(ECOG)per-formance status(PS)score,TG level,TC level,TT,PT,APTT,FIB level,D-D level,and platelet count might be influ-encing factors for the occurrence of VTE in NSCLC immunotherapy patients(P<0.05).Multivariate Logistic regression analysis showed that ECOG PS score≥2 points,TG>1.7 mmol/L,TC>5.2 mmol/L,and D-D≥0.5 mg/L were all inde-pendent risk factors for VTE occurrence in NSCLC immunotherapy patients(P<0.05).Conclusion NSCLC immuno-therapy patients have a higher risk of VTE,with ECOG PS score≥2 points,TG>1.7 mmol/L,TC>5.2 mmol/L,and D-D≥0.5 mg/L being independent risk factors for VTE in NSCLC immunotherapy patients.
NETL
NSTL
万方数据
维普
