Clinical characteristic and prognosis of patients with Paget's disease of the breast
Objective To investigate the clinical characteristic and prognosis of patients with Paget's disease of the breast.Method The clinical data of 71 patients with Paget's disease of the breast were collected,and the clinical charac-teristics and prognosis of the patients were analyzed.Multivariate Cox regression analysis method was used to analyze the prognostic influencing factors of patients with Paget's disease of the breast.Result The mean age of 71 patients with Paget's disease of the breast at diagnosis was 56.42 years(32-89 years).There were 7 patients with simple Paget's disease,36 patients with invasive carcinoma,and 28 patients with carcinoma in situ.The median follow-up time of 71 pa-tients with Paget's disease of the breast was 108 months(24-245 months),and the 2-,5-year disease-free survival rates were 91.5%(65/71)and 62.0%(44/71),respectively.Advanced T stage,advanced N stage and positive progesterone re-ceptor(PR)were risk factors for the prognosis of Paget's disease of the breast with invasive carcinoma(P<0.05).Ad-vanced N stage was risk factor for the prognosis of Paget's disease of the breast(P<0.05).Conclusion N stage is the prognostic factor of patients with Paget's disease of the breast,and T,N stages and PR status are prognostic factors of pa-tients with Paget's disease of the breast and invasive carcinoma.
breast cancerPaget's disease of the breastclinical characteristicprognosis
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