Effect of transcatheter arterial chemoembolization treatment interval on liver function,coagulation function and immune function of elderly patients with primary liver cancer
Objective To explore the effect of transcatheter arterial chemoembolization(TACE)treatment interval on liver function,coagulation function and immune function of elderly patients with primary liver cancer.Method A total of 96 elderly patients with primary liver cancer were divided into short interval group(n=50,the interval between two TACE treatments≤61 days)and long interval group(n=46,the interval between two TACE treatments>61 days)accord-ing to the difference of TACE treatment interval.The liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)],coagulation function indexes[activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),D-dimer(D-D)]and immune function indexes(CD3+,CD4+,CD8+ and CD4+/CD8+)were compared between the two groups.Result Before the first surgery and 6 days after the first sur-gery,there were no significant differences in ALT,AST,TBIL,APTT,PT,TT,D-D,CD3+,CD4+,CD8+ and CD4+/CD8+ between the two groups(P>0.05).Before the second surgery and 6 days after the second surgery,the ALT,AST,TBIL,D-D and CD8+ levels in the short interval group were lower than those in the long interval group,APTT was longer than that in the long interval group,and CD3+,CD4+ levels and CD4+/CD8+ were higher than those in the long interval group,and the differences were statistically significant(P<0.05).Conclusion Shorter TACE treatment interval has less damage to liver function,coagulation function and immune function in elderly patients with primary liver cancer.It is suggested that reasonable selection of TACE treatment interval should be made according to the patient's condition.
primary liver cancertranscatheter arterial chemoembolizationliver functioncoagulation functionim-mune function
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