Application effect of sequential nasal high-flow oxygen therapy after mechanical ventilation and extubation in patients with severe lung cancer
Objective To explore the application effect of sequential nasal high-flow oxygen therapy after mechani-cal ventilation and extubation in patients with severe lung cancer.Method A total of 80 patients with severe lung cancer were divided into control group(n=39)and observation group(n=41)according to different treatment methods.Among them,the control group was treated with non-invasive positive pressure ventilation after mechanical ventilation and extu-bation,and the observation group was treated with sequential nasal high-flow oxygen therapy after mechanical ventilation and extubation.The respiratory rate,heart rate,recovery indicators,blood gas indicators[pH value,pulse oxygen satura-tion(SpO2),arterial partial pressure of carbon dioxide(PaCO2)/inspired oxygen concentration(FiO2)],reintubation status,and incidence of complications were compared between two groups.Result Two hours after treatment,the respiratory rate and heart rate in the two groups were lower than those before treatment,and the respiratory rate,heart rate in the ob-servation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total mechanical ventilation time and intensive care unit(ICU)stay time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).Twelve hours after treatment,the SpO2 in the two groups were higher than those before treatment,the pH value and PaCO2/FiO2 in the two groups were lower than those before treatment,the SpO2,PaCO2/FiO2 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The reintubation rate in the observation group was 2.44%,which was not statistically significant compared with 5.13%in the control group(P>0.05).The total incidence of complications in the observation group was 4.88%,which was lower than 23.08%in the control group,and the difference was statistical-ly significant(P<0.05).Conclusion Sequential nasal high-flow oxygen therapy after mechanical ventilation and extuba-tion can shorten the mechanical ventilation time,improve the blood gas indicators of severe lung cancer patients,promote recovery of patients,and have high safety.
severe lung cancersequential nasal high-flow oxygen therapyblood gas indicator
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