细胞减灭术联合腹腔热灌注化疗对子宫内膜癌患者减瘤满意率及预后的影响
Effect of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy on the tumor reduction satisfaction rate and prognosis of patients with endometrial cancer
李娜 1苏婷婷 2程艳丽 1韩媛媛3
作者信息
- 1. 西安高新医院妇产科,西安 710061
- 2. 西安庆华医院妇产科,西安 710025
- 3. 镇巴县人民医院超声科,陕西 汉中 723600
- 折叠
摘要
目的 探究细胞减灭术(CDS)联合腹腔热灌注化疗(HIPEC)对子宫内膜癌(EC)患者减瘤满意率及预后的影响.方法 将124例EC患者按治疗方案的不同分为研究组和对照组,每组62例.对照组采用CDS和紫杉醇+卡铂治疗,研究组在对照组的基础上联合HIPEC治疗.比较两组患者手术时间、术中腹腔积液量、临床疗效、生存率、不良反应发生情况、复发情况.结果 研究组患者手术时间明显短于对照组,术中腹腔积液量明显少于对照组,差异均有统计学意义(P﹤0.01).研究组患者总有效率、减瘤满意率均高于对照组,差异均有统计学意义(P﹤0.05).术后24个月,研究组患者生存率明显高于对照组,差异有统计学意义(P﹤0.01).研究组患者恶心、麻木发生率及复发率均低于对照组,差异均有统计学意义(P﹤0.05).结论 CDS联合HIPEC治疗EC效果较好,可缩短手术时间,减少术中腹腔积液量,增加减瘤满意率,提高患者生存率.
Abstract
Objective To explore the effect of cytoreductive surgery(CDS)combined with hyperthermic intraperito-neal chemotherapy(HIPEC)on the tumor reduction satisfaction rate and prognosis of patients with endometrial cancer(EC).Method A total of 124 patients with EC were divided into study group and control group according to different treatment regimens,with 62 cases in each group.The control group was treated with CDS and paclitaxel combined with carboplatin,and the study group was treated with HIPEC on the basis of the control group.The operation time,intraopera-tive peritoneal effusion volume,clinical efficacy,survival rate,adverse reactions and recurrence were compared between the two groups.Result The operation time of the study group was significantly shorter than that of the control group,and the volume of intraoperative peritoneal effusion was significantly less than that of the control group,the differences were statistically significant(P<0.01).The total effective rate and tumor reduction satisfaction rate in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).At 24 months after op-eration,the survival rate of the study group was significantly higher than that of the control group,the difference was sta-tistically significant(P<0.01).The incidence of nausea,numbness and recurrence rate in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion CDS combined with HIPEC is effective in the treatment of EC,which can shorten the operation time,reduce the volume of intraoperative peri-toneal effusion,increase the tumor reduction satisfaction rate,and improve the survival rate of patients.
关键词
细胞减灭术/腹腔热灌注化疗/子宫内膜癌/减瘤满意率Key words
cytoreductive surgery/hyperthermic intraperitoneal chemotherapy/endometrial cancer/tumor reduction satisfaction rate引用本文复制引用
出版年
2024
NETL
NSTL
万方数据