Correlation between long non-coding RNA gene polymorphisms and genetic susceptibility of primary liver cancer
Objective To investigate the correlation between gene single nucleotide polymorphisms(SNP)of long non-coding RNA(lncRNA)and genetic susceptibility of primary liver cancer,and to provide basis for the early diagnosis,prevention and the study of genetic susceptibility mechanism of liver cancer.Method A total of 41 patients with prima-ry liver cancer and 83 healthy volunteers were selected as the case group and the control group,respectively.Plasmacyto-ma variant translocation 1(PVT1),colon cancer associated transcript 1(CCAT1),colon cancer associated transcript 2(CCAT2),cancer susceptibility 8(CASC8),prostate cancer associated non-coding RNA 1(PRNCR1)were genotyped for 13 SNP loci.The genotype distribution was compared between the two groups.Result The difference was statistically significant in the genotype distribution of RS2392885 locus of lncRNA PVT1 gene between the case group and the con-trol group(P＜0.05),and there were no significant differences in the genotype distribution of other loci(P＞0.05).The gen-otypes of RS2392885 locus in lncRNA PVT1 gene were CC,CT and TT types,and the proportions of each genotype in the case group were 12.2％,68.3％and 19.5％,respectively,and those in the control group were 19.3％,42.2％and 38.6％,respectively.Conclusion The genotype of RS2392885 locus in lncRNA PVT1 may be associated with the genet-ic susceptibility of primary liver cancer.
万方数据
维普
