Objective To explore the diagnostic value and safety of ultrasound-guided puncture biopsy combined with contrast-enhanced ultrasound for peripheral lung cancer.Method A total of 193 patients with suspected peripheral lung cancer were selected,all patients underwent ultrasound-guided puncture biopsy and contrast-enhanced ultrasound ex-amination.The surgical pathological examination results was used as the gold standard,the diagnostic value of ultrasound-guided puncture biopsy and contrast-enhanced ultrasound single and combined examination for peripheral lung cancer were analyzed,and the incidence of complications between the two examination methods were compared.Result The pathological results showed that,in 193 suspected peripheral lung cancer patients,132 were positive and 61 were nega-tive.A total of 114 cases were diagnosed as positive and 79 cases were diagnosed as negative by ultrasound-guided punc-ture biopsy,and 121 cases were diagnosed as positive and 72 cases were diagnosed as negative by contrast-enhanced ultra-sound,and 129 cases were diagnosed as positive and 64 cases were diagnosed as negative by combining of the two exami-nations.The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of ultrasound-guid-ed puncture biopsy combined with contrast-enhanced ultrasound examination in diagnosing peripheral lung cancer were higher than those of the single examination.The total incidence of complications during ultrasound-guided puncture biop-sy was 3.11％,which was not statistically significant compared to 2.07％in contrast-enhanced ultrasound examination(P＞0.05).Conclusion The combination of ultrasound-guided puncture biopsy combined with contrast-enhanced ultrasound has high diagnostic value for peripheral lung cancer,and the combined examination can improve diagnostic efficiency and safety.
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