Clinical efficacy and prognosis evaluation of microsurgical tumor resection combined with isotope therapy for brain glioma
Objective To investigate the clinical efficacy and prognosis evaluation of microsurgical tumor resection combined with isotope therapy for brain glioma.Method A total of 80 patients with brain glioma undewent surgery were divided into operation group(n=37)and combined group(n=43)according to different treatment methods.The oper-ation group received microsurgical tumor resection,and the combined group received microsurgical tumor resection com-bined with isotope therapy.The clinical efficacy,serum indexes[vascular endothelial growth factor(VEGF),glial fibril-lary acidic protein(GFAP),β-endorphin(β-EP),3-nitrotyrosine(3-NT)],cognitive function[mini-mental state examina-tion(MMSE),Montreal cognitive assessment scale(MoCA)],health status[Karnofsky performance status(KPS)score],ability of daily living[activity of daily living scale(ADL)],incidence of complications and prognosis were compared be-tween two groups.Result The total clinical effective rate in the combined group was higher than that in the operation group,and the recurrence rate was lower than that in the operation group,and the differences were statistically significant(P＜0.05).At three months after surgery,there were no significant differences in β-EP and 3-NT levels between two groups(P＞0.05);the levels of VEGF and GFAP in combined group were lower than those in operation group,and the dif-ferences were statistically significant(P＜0.05).At one year after surgery,there were no significant differences in MMSE and MoCA scores between two groups(P＞0.05);the KPS and ADL scores in combined group were higher than those in operation group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of complications between the two groups(P＞0.05).Conclusion Microscopical tumor resection combined with isotope therapy for brain glioma is safe and reliable,which can improve clinical efficacy,improve patients'cognitive function and quality of life,and reduce the incidence of complications and recurrence.
万方数据
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