摘要
目的 探讨头颈部恶性肿瘤(HNC)患者放疗后发生吞咽困难的影响因素.方法 根据放疗后是否发生吞咽困难将117例HNC患者分为观察组(n=48,发生吞咽困难)和对照组(n=69,未发生吞咽困难).比较两组患者的临床资料,采用二元Logistic回归模型分析HNC患者放疗后发生吞咽困难的影响因素.结果 两组患者的性别、吸烟史、肿瘤位置、放射剂量比较,差异均有统计学意义(P＜0.05).多因素Logistic回归分析结果显示,男性、肿瘤位于颈部和耳鼻喉部、高放射剂量均是HNC患者放疗后发生吞咽困难的独立危险因素(P＜0.05).结论 男性、肿瘤位于颈部和耳鼻喉部、高放射剂量均是HNC患者放疗后发生吞咽困难的独立危险因素,临床工作者应予以重视.
Abstract
Objective To explore the influencing factors of dysphagia in patients with head and neck cancer(HNC)after radiotherapy.Method A total of 117 patients with HNC were divided into observation group(n=48,dysphagia)and control group(n=69,no dysphagia)according to whether dysphagia occurred after radiotherapy.The clinical data of the two groups were compared,and the influencing factors of dysphagia in HNC patients after radiotherapy were ana-lyzed by binary Logistic regression model.Result There were significant differences in gender,smoking history,tumor location and radiation dose between the two groups(P＜0.05).Multivariate Logistic regression analysis showed that male,tumor location in the neck,ear,nose and throat,and high radiation dose were independent risk factors for dyspha-gia in HNC patients after radiotherapy(P＜0.05).Conclusion Male,tumor location in the neck,ear,nose and throat,and high radiation dose are independent risk factors for dysphagia in HNC patients after radiotherapy,clinical staff should pay attention to it.
维普
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