Clinical significance of monitoring N-terminal pro-brain natriuretic peptide level in perioperative acute heart failure in patients with lung cancer
Objective To investigate the clinical significance of monitoring N-terminal pro-brain natriuretic peptide(NT-proBNP)levels in perioperative acute heart failure(AHF)in patients with lung cancer.Method A total of 40 pa-tients with lung cancer who underwent surgery were selected,and the serum NT-proBNP levels were detected at 2 h be-fore surgery,during surgery,and 2 h after surgery.The changes in serum NT-proBNP levels during the perioperative peri-od were analyzed.Result The serum NT-proBNP levels in 40 patients with lung cancer at 2 h before surgery,during sur-gery,and 2 h after surgery were compared,the difference was statistically significant(P<0.01).During surgery and 2 h af-ter surgery,the serum NT-proBNP levels in patients with lung cancer were higher than those 2 h before surgery,and the differences were statistically significant(P<0.05).A total of 37 cases had higher serum NT-proBNP levels during surgery compared to 2 h before surgery,and 38 cases had higher serum NT-proBNP levels at 2 h after surgery compared to 2 h be-fore surgery.Although the serum NT-proBNP levels in most patients decreased compared to during surgery,they were still higher than preoperative levels at 2 h before surgery.Among 40 patients with lung cancer,27 cases underwent thora-coscopic partial lobectomy and 13 cases underwent thoracoscopic lobectomy.During surgery and 2 h after surgery,the se-rum NT-proBNP levels in patients undergoing thoracoscopic partial lobectomy were significantly higher than those in 2 h before surgery,and the differences were statistically significant(P<0.01).Among them,25 cases had higher serum NT-proBNP levels during surgery than 2 h before surgery,and 26 cases had higher serum NT-proBNP levels at 2 h after sur-gery than 2 h before surgery.During surgery and 2 h after surgery,the serum NT-proBNP levels in patients undergoing thoracoscopic lobectomy were significantly higher than 2 h before surgery,the differences were statistically significant(P<0.01).Among them,12 cases had higher serum NT-proBNP levels during surgery than 2 h before surgery,and 12 cas-es had higher serum NT-proBNP levels at 2 h after surgery than 2 h before surgery.Conclusion Perioperative monitor-ing of serum NT-proBNP levels provides an important reference for reducing the incidence of AHF in patients with lung cancer and improving surgical safety.
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