Clinical efficacy of fractioned stereotactic radiotherapy combined with whole brain radiotherapy in the treatment of breast cancer patients with brain metastasis
Objective To explore the clinical efficacy of fractioned stereotactic radiotherapy(FSRT)combined with whole brain radiotherapy in the treatment of breast cancer patients with brain metastasis.Method A total of 140 breast cancer patients with brain metastasis were divided into observation group and control group,with 70 cases in each group.The control group received whole brain radiotherapy,and the observation group received FSRT combined with whole brain radiotherapy.The short-term efficacy,quality of life[Karnofsky performance status(KPS)score],serological indica-tors[C-C motif chemokine ligand 20(CCL20),monocyte chemoattractant protein-1(MCP-1),vascular endothelial growth factor(VEGF)],adverse reactions and survival of the two groups were compared.Result The total effective rate of the observation group was 88.57%,which was significantly higher than 68.57%of the control group,and the differenc-es were statistically significant(P<0.01).After treatment,the KPS scores in the two groups were higher than those before treatment,and the KPS score in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the serum levels of CCL20,MCP-1 and VEGF in the two groups were lower than those before treatment,and the serum levels of CCL20,MCP-1 and VEGF in the observation group were low-er than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of ad-verse reactions in the observation group was 5.71%,which was lower than 18.57%in the control group,and the differ-ence was statistically significant(P<0.05).The 1-year survival rate of the observation group was 94.29%,which was high-er than 80.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion FSRT com-bined with whole brain radiotherapy can improve the short-term and long-term efficacy,improve the quality of life,and reduce the serum levels of CCL20,MCP-1 and VEGF in the treatment of breast cancer patients with brain metastasis,and has good safety.
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