首页|急诊手术与支架扩张后择期手术治疗右半结肠癌合并急性肠梗阻患者效果的比较

急诊手术与支架扩张后择期手术治疗右半结肠癌合并急性肠梗阻患者效果的比较

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目的 比较急诊手术与支架扩张后择期手术治疗右半结肠癌合并急性肠梗阻患者的效果.方法 根据治疗方式的不同将96例右半结肠癌合并急性肠梗阻患者分为对照组(n=46,急诊手术)和观察组(n=50,支架扩张后择期手术),比较两组患者的围手术期指标、胃肠激素指标[胃动素(MTL)、胃泌素(GAS)、血管活性肠肽(VIP)]、炎性因子指标[白细胞介素(IL)-6、IL-8、肿瘤坏死因子-α(TNF-α)]、术后并发症发生情况及生存情况.结果 观察组患者术中出血量少于对照组,首次肛门排气时间、流质饮食恢复时间、术后住院时间均短于对照组,淋巴结清扫数目多于对照组,差异均有统计学意义(P﹤0.05).手术后,两组患者MTL、GAS、VIP、IL-6、IL-8、TNF-α水平均低于本组手术前,观察组患者MTL、GAS、VIP水平均高于对照组,IL-6、IL-8、TNF-α水平均低于对照组,差异均有统计学意义(P﹤0.05).观察组患者的术后并发症总发生率低于对照组,3年生存率高于对照组,差异均有统计学意义(P﹤0.05).结论 与急诊手术比较,支架扩张后择期手术治疗右半结肠癌合并急性肠梗阻患者,可以减少术中出血量,增加淋巴结清扫数目,促进术后恢复,降低胃肠激素和炎性因子水平,减少术后并发症,提高术后生存率.
Comparison of the effect of emergency surgery and elective surgery after stent dilation in the treatment of right colon cancer patients complicated with acute intestinal obstruction
Objective To compare the effect of emergency surgery and elective surgery after stent dilation in the treat-ment of right colon cancer patients complicated with acute intestinal obstruction.Method A total of 96 right colon can-cer patients complicated with acute intestinal obstruction were divided into control group(n=46,emergency surgery)and observation group(n=50,elective surgery after stent dilation)according to different treatment methods.The perioperative period indexes,gastrointestinal hormone indexes[motilin(MTL),gastrin(GAS),vasoactive intestinal peptide(VIP)],in-flammatory factor indexes[interleukin(IL)-6,IL-8,tumor necrosis factor-α(TNF-α)],incidence of complications after surgery and survival were compared between the two groups.Result The amount of intraoperative blood loss in observa-tion group was significantly less than that in control group,the first time of anal exhaust,recovery time of liquid diet and postoperative hospital stay were significantly shorter than those in control group,the number of lymph node dissection was significantly higher than that in control group,and the differences were statistically significant(P<0.05).After sur-gery,the levels of MTL,GAS,VIP,IL-6,IL-8 and TNF-α in two groups were lower than those before surgery,the levels of MTL,GAS and VIP in observation group were higher than those in control group,the levels of IL-6,IL-8 and TNF-α were lower than those in control group,and the differences were statistically significant(P<0.05).The total incidence of postoperative complications in observation group was lower than that in control group,and the 3-year survival rate was higher than that in control group,and the differences were statistically significant(P<0.05).Conclusion Compared with emergency surgery,elective surgery after stent dilation can reduce intraoperative blood loss,increase the number of lymph node dissection,promote postoperative recovery,reduce the levels of gastrointestinal hormones and inflammatory factors,reduce postoperative complications,and improve postoperative survival rate.

emergency surgerystent dilationelective surgeryright colon canceracute intestinal obstruction

周明丽、刘影、康长娟

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信阳市中心医院急诊内科,河南 信阳 4640000

急诊手术 支架扩张 择期手术 右半结肠癌 急性肠梗阻

2024

癌症进展
中国医学科学院,北京协和医学院

癌症进展

影响因子:1.004
ISSN:1672-1535
年,卷(期):2024.22(8)