Diagnostic and prognostic prediction value of platelet,D-dimer,fibrinogen,interleukin-37 and CD24 in the epithelial ovarian cancer
Objective To investigate the diagnostic and prognostic prediction value of platelet(PLT),D-dimer(D-D),fibrinogen(FIB),interleukin-37(IL-37)and CD24 in epithelial ovarian cancer(EOC).Method A total of 60 EOC pa-tients,60 benign ovarian tumor patients,and 60 healthy individuals were selected,which were included in the EOC group,benign group,and healthy group,respectively.Plasma PLT,D-D,FIB levels and serum IL-37,CD24 levels among three groups of subjects and EOC patients with different prognostic were compared.The receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,the diagnostic efficacy of PLT,D-D,FIB,IL-37,and CD24 single and combined detection,as well as their predictive prognosis efficacy for the EOC patients were evaluat-ed.Result The PLT,D-D,FIB,IL-37 and CD24 levels in EOC group were higher than those in benign group and healthy group(P<0.05),and the above levels in benign group were higher than those in healthy group(P<0.05).ROC curve showed that the sensitivity,specificity and accuracy of the combined detection of PLT+D-D+FIB+IL-37+CD24 in diag-nosing EOC were higher than those of single detection of various indicators,and the differences were statistically signifi-cant(P<0.05).After 6 months follow-up,among the 60 EOC patients,48 cases survived and 12 cases died.Plasma PLT,D-D,FIB levels and serum IL-37,CD24 level of died EOC patients were higher than those of survived patients,and the differences were statistically significant(P<0.05).ROC curve showed that the sensitivity and accuracy of the combined detection of PLT+D-D+FIB+IL-37+CD24 in predicting prognosis of EOC patients were higher than those of single and combined detection of various indicators,and the differences were statistically significant(P<0.05).Conclusion The sensitivity,specificity and accuracy of combined detection of PLT,D-D,FIB,IL-37 and CD24 in diagnosing EOC and predicting prognosis are high,and it has high value in the diagnosis and prognosis evaluation of EOC.
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