Expression of thymidine kinase 1 and cyto-keratin 19 fragment antigen 21-1 in non-small cell lung cancer and their relationship with clinical features and prognosis
Objective To investigate the expression of thymidine kinase 1(TK1)and cyto-keratin 19 fragment anti-gen 21-1(CYFRA21-1)in non-small cell lung cancer(NSCLC)and their relationship with clinical features and progno-sis.Method A total of 100 NSCLC patients were selected,and the expression of TK1 and CYFRA21-1 in tumor tissues and adjacent tissues were detected by immunohistochemical method.The expression of TK1 and CYFRA21-1 in tumor tissues and adjacent tissues,and NSCLC patients with different clinical features were compared.According to the progno-sis,NSCLC patients were divided into poor prognosis group and good prognosis group.Logistic regression analysis was used to analyze the influencing factors on prognosis of NSCLC patients.Result The positive expression rates of TK1 and CYFRA21-1 in tumor tissues were significantly higher than those in adjacent tissues,and the differences were statisti-cally significant(P<0.01).The positive expression rates of TK1 and CYFRA21-1 in NSCLC patients with different lymph node metastasis were compared,and the differences were statistically significant(P<0.05).Lymph node metasta-sis,expression of TK1 and CYFRA21-1 in good prognosis group(n=71)and poor prognosis group(n=29)were com-pared,and the differences were statistically significant(P<0.05).Lymph node metastasis,positive expression of TK1 and CYFRA21-1 were independent risk factors for poor prognosis in NSCLC patients(P<0.05).Conclusion The positive ex-pression rates of TK1 and CYFRA21-1 in NSCLC are high,and lymph node metastasis,positive expression of TK1 and CYFRA21-1 are risk factors for poor prognosis in NSCLC patients.
non-small cell lung cancerthymidine kinase 1cyto-keratin 19 fragment antigen 21-1prognosis
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