Analysis of clinical features and prognostic factors in breast cancer patients with low and zero expression of human epidermal growth factor receptor 2
Objective To investigate the clinical features and prognostic factors in breast cancer patients with low and zero expression of human epidermal growth factor receptor 2(HER2).Method A total of 653 HER2 negative breast cancer patients were divided into patients with low and zero expression of HER2 according to the result of immunohisto-chemistry(IHC).The clinical features and survival of breast cancer patients with low and zero expression of HER2 were compared.The influencing factors of disease-free survival(DFS)and overall survival(OS)in HER2 negative breast can-cer patients were analyzed by Cox proportional risk model.Result The positive expression rate of hormone receptor(HR)in breast cancer patients with low expression of HER2 was significantly higher than that of patients with zero ex-pression of HER2,and the difference was statistically significant(P＜0.01).There were no significant differences in OS and DFS between breast cancer patients with low and zero expression of HER2(P＞0.05).TNM stage Ⅲ and Ki-67≥14％were independent risk factors for OS and DFS in HER2 negative breast cancer patients(P＜0.05).Conclusion The posi-tive expression rate of HR in breast cancer patients with is higher,but low expression of HER2 can not be considered as new molecular subtype related to prognosis at present.TNM stage Ⅲ and Ki-67≥14％are independent risk factors for OS and DFS in HER2 negative breast cancer patients,which can be used as a reference for treatment strategies of HER2 nega-tive breast cancer patients.
breast cancerhuman epidermal growth factor receptor 2prognosisclinical feature
万方数据
维普
