Diagnostic value of multiparametric MRI for Gleason grading of prostate cancer
Objective To explore the diagnostic value of multiparametric MRI(mpMRI)for Gleason grading of pros-tate cancer.Method A total of 126 patients with prostate cancer received routine MRI,dynamic enhanced MRI and dif-fusion weighted imaging(DWI)examination.The imaging parameters of prostate cancer patients with different Gleason grades were compared.The correlation between DWI apparent diffusion coefficient(ADC)value and Gleason grading of prostate cancer were analyzed by Spearman method.The prostate cancer patients were divided into low grade prostate cancer group(grade 1 to 2)and high grade prostate cancer group(grade 3 to 5)according to the Gleason grading results.The diagnostic value of DWI ADC value for high grade prostate cancer were analyzed by receiver operating characteris-tic(ROC)curve and area under the curve(AUC).Result There were significant differences in DWI ADC values in pros-tate cancer patients with different Gleason grades(P＜0.05).The DWI ADC value was negatively correlated with Gleason grading of prostate cancer(P＜0.05).The AUC of DWI ADC value in diagnosing high grade prostate cancer was 0.813(95％CI:0.740-0.886),the sensitivity and specificity were both 0.754,and cut-off value was 0.792× 10-3 mm2/s.Conclu-sion mpMRI has an important reference value in the diagnosis of Gleason grading of prostate cancer,and when the DWI ADC value is 0.792× 10-3 mm2/s,its specificity and sensitivity in the diagnosis of high grade prostate cancer are high.
multiparametric MRIprostate cancerGleason gradingdiagnostic value
万方数据
维普
