Effect of surgery combined with chemotherapy on immune function in children with neuroblastoma
Objective To investigate the effect of surgery combined with chemotherapy on immune function in chil-dren with neuroblastoma.Method A total of 98 children with neuroblastoma were divided into control group(n=48)and observation group(n=50)according to different treatment methods.The control group received surgery,and the observa-tion group received chemotherapy combined with surgery.The levels of serum tumor markers,immunoglobulin,cellular immune indexes and the incidence of adverse reactions were compared between the two groups.Result After treatment,the levels of matrix metalloproteinase 2(MMP2),matrix metalloproteinase 1(MMP1)and vascular endothelial growth factor(VEGF)in the two groups were lower than those before treatment,and the levels of MMP2,MMP1 and VEGF in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).After treatment,the levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)in the two groups were lower than those before treatment,the levels of IgA,IgG and IgM in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).After treatment,the levels of total T lymphocyte(TTL)in both groups were lower than those before treatment,while helper T lymphocyte(THL),suppressor T lymphocyte(TSL)and natural killer(NK)cell levels were higher than those before treatment,the levels of TTL,THL,TSL and NK cell in observation group were higher than those in control group,the differences were statistically signifi-cant(P＜0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Surgery combined with chemotherapy can improve immune function and inhibit tumor invasion and metastasis in children with neuroblastoma.
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