尿液循环肿瘤DNA在膀胱癌早期诊断及预后预测中的价值
Value of urine circulating tumor DNA in early diagnosis and prognostic prediction of bladder cancer
吴岑 1陈家俊 1李联川 1伍伯聪 1张巍 1洪泓长 1张文彬 1魏晓宇1
作者信息
- 1. 福建医科大学附属泉州第一医院泌尿外科,福建 泉州 362000
- 折叠
摘要
目的 探讨尿液循环肿瘤DNA(ctDNA)在膀胱癌早期诊断及预后预测中的价值.方法 选取68例膀胱癌患者作为观察组,77例健康体检者作为对照组.比较两组患者的尿液ctDNA浓度,采用多因素Logistic回归模型分析膀胱癌患者预后的影响因素.绘制受试者工作特征(ROC)曲线,分析ctDNA对早期膀胱癌的诊断价值及对预后的预测价值.结果 观察组患者尿液ctDNA浓度明显高于对照组,差异有统计学意义(P﹤0.01).尿液ctDNA诊断早期膀胱癌的灵敏度为0.868,特异度为0.985,ROC曲线的曲线下面积为0.975(95%CI:0.953～0.996).多因素Logistic回归分析结果显示,ctDNA浓度是早期膀胱癌患者预后的影响因素(P﹤0.05).尿液ctDNA预测早期膀胱癌患者预后的灵敏度为0.833,特异度为0.860,曲线下面积为0.864(95%CI:0.759～0.970).结论 检测尿液中ctDNA的浓度有助于诊断膀胱癌,且操作简单方便、无创伤性.尿液中ctDNA浓度对膀胱癌预后具有一定的预测价值,且特异度和灵敏度较高.
Abstract
Objective To investigate the value of urine circulating tumor DNA(ctDNA)in early diagnosis and prog-nostic prediction of bladder cancer.Method A total of 68 patients with bladder cancer were selected as observation group and 77 healthy subjects were selected as control group.The concentration of urine ctDNA was compared between the two groups,and the influencing factors of the prognosis of bladder cancer patients were analyzed by multivariate Lo-gistic regression model.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of ctD-NA in early bladder cancer and the predictive value of prognosis.Result The urine ctDNA concentration in the observa-tion group was significantly higher than that in the control group,the difference was statistically significant(P<0.01).The sensitivity and specificity of urine ctDNA in diagnosing early bladder cancer were 0.868,0.985,and the area under the curve was 0.975(95%CI:0.953-0.996).Multivariate Logistic regression analysis showed that ctDNA concentration was influencing factor for the prognosis of early bladder cancer patients(P<0.05).The sensitivity and specificity of urine ctD-NA in predicting the prognosis of early bladder cancer patients were 0.833,0.860,and the area under the curve was 0.864(95%CI:0.759-0.970).Conclusion The detection of ctDNA concentration in urine is helpful for the diagnosis of bladder cancer,and the operation is simple,convenient and non-invasive.The concentration of ctDNA in urine can predict the prognosis of bladder cancer,and the specificity and sensitivity are high.
关键词
尿液/循环肿瘤DNA/膀胱癌/早期诊断/预后预测Key words
urine/circulating tumor DNA/bladder cancer/early diagnosis/prognostic prediction引用本文复制引用
基金项目
2020年度福建省自然科学基金(2020J011277)
出版年
2024
NETL
NSTL
万方数据