Application effect of gemcitabine combined with S-1 in patients with pancreatic cancer after surgery
Objective To investigate the application effect of gemcitabine combined with S-1 in patients with pancre-atic cancer after surgery.Method A total of 86 patients with pancreatic cancer were divided into control group(n=42)and observation group(n=44)according to different postoperative treatment methods.Patients in the control group re-ceived S-1 treatment at the 6th week after surgery,and patients in the observation group received gemcitabine treatment on the basis of the control group.The clinical efficacy,tumor markers[carbohydrate antigen 125(CA125),carcinoembry-onic antigen(CEA),cell migration inducing hyaluronan binding protein(CEMIP)]levels,immune function indicators(CD3+,CD4+,CD8+)and the occurrence of adverse reactions were compared between the two groups.Result The total effective rate of the observation group was 45.45%,which was higher than 21.43%of the control group,the difference was statistically significant(P<0.05).After treatment,the CEA,CA125 and CEMIP levels in both groups were lower than those before treatment,and the CEA,CA125 and CEMIP levels in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CD3+and CD4+in both groups were higher than those before treatment,the levels of CD8+were lower than those before treatment,and the levels of CD3+and CD4+in observation group were higher than those in control group,while the level of CD8+was lower than that in control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Gemcitabine combined with S-1 can improve clinical efficacy,reduce serum tumor marker levels,and improve immune function without increasing adverse re-actions in patients with pancreatic cancer after surgery.
pancreatic cancergemcitabineS-1clinical efficacytumor markerimmune function
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