Predictive value of leukocyte derived markers combined detection for infection in malignant tumor patients after chemotherapy
Objective To explore the predictive value of leukocyte derived markers[neutrophil-to-lymphocyte ratio(NLR),lymphocyte-to-monocyte ratio(LMR),platelet-to-lymphocyte ratio(PLR)]combined detection for infection in malignant tumor patients after chemotherapy.Method A total of 115 malignant tumor patients after chemotherapy were selected and divided into infected group(n=80)and uninfected group(n=35)based on whether infection occurred after chemotherapy.The NLR,PLR,and LMR were compared between the infected and uninfected groups,as well as malig-nant tumor chemotherapy patients with different infection types.The receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,and the predictive efficacy of NLR,PLR,and LMR single and combined detection for infection in malignant tumor patients after chemotherapy were evaluated.Result The NLR and PLR of the infected group were significantly higher than those of the uninfected group,while the LMR was significantly lower than that of the uninfected group,and the differences were statistically significant(P<0.01).Among the malignant tumor chemotherapy patients in the infection group,there were 42 cases of bacterial infection,20 cases of viral infection,and 18 cases of mixed infection.The NLR and PLR of bacterial infection patients were higher than those of viral infec-tion and mixed infection patients,and the LMR was lower than that of viral infection and mixed infection patients,in ad-dition,the NLR and PLR of mixed infection patients were higher than those of viral infection patients,and the LMR was lower than that of viral infection patients,and the differences were statistically significant(P<0.05).ROC curve showed that the AUC of NLR,PLR,and LMR combined detection in predicting infection in malignant tumor patients after che-motherapy was 0.949(95%CI:0.905-0.993),specificity was 0.947,which were higher than the single detection of each in-dicator.Conclusion The leukocyte derived markers NLR,PLR,and LMR combined detection has high value in predict-ing infection in malignant tumor patients after chemotherapy,and can be used as effective indicators for evaluating infec-tion in malignant tumor patients after chemotherapy.
leukocyte derived markermalignant tumorchemotherapyinfectionpredictive value
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