Clinical significance of serum D-dimer,lactate dehydrogenase and ischemia-modified albumin detection in patients with acute pulmonary embolism after lung cancer surgery
Objective To investigate the clinical significance of serum D-dimer(D-D),lactate dehydrogenase(LDH)and ischemia-modified albumin(IMA)detection in patients with acute pulmonary embolism(APE)after lung cancer sur-gery.Method A total of 125 patients with lung cancer undergoing surgical treatment were selected as the observation group,and 113 healthy subjects were selected as the control group.Serum D-D,LDH and IMA levels were compared be-tween the two groups.The observation group was divided into APE group(30 cases)and non-APE group(95 cases)ac-cording to whether APE occurred after lung cancer surgery,the clinical characteristics of the two groups were compared.Multiple Logistic regression analysis was used to analyze the influencing factors of postoperative APE in patients with lung cancer.The diagnostic efficacy of D-D,LDH and IMA single and combined detection in the diagnosis of APE after lung cancer surgery were compared.Result Serum D-D,LDH and IMA levels in observation group were significantly higher than those in control group,the differences were statistically significant(P<0.01).There were significant differenc-es in the underlying diseases,pathological types,TNM stages and serum D-D,LDH,IMA levels between APE group and non-APE group(P<0.05).Multiple Logistic regression analysis showed that the underlying disease,pathological type of adenocarcinoma,TNM stage Ⅲ,D-D>0.50 mg/L,LDH<109 U/L or>245 U/L,IMA>0.29 ABSU were risk factors for APE after lung cancer surgery(P<0.05).The sensitivity,specificity and accuracy of D-D,LDH and IMA single and com-bined detection in the diagnosis of APE after lung cancer surgery were 93.33%,95.79%and 95.20%,respectively,which were higher than those of the three indexes single detection.Conclusion Serum D-D,LDH and IMA detection have cer-tain clinical significance in the diagnosis of APE after lung cancer surgery,and their combined detection has higher diag-nostic efficacy for APE after lung cancer surgery,which is of great significance for clinical treatment.
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