Value of CT arterial enhancement fraction,alpha-fetoprotein variant 3,and neutrophil-lymphocyte ratio combined detection in evaluating the efficacy of interventional chemotherapy for liver cancer patients
Objective To explore the value of CT arterial enhancement fraction(AEF),alpha-fetoprotein variant 3(AFP-L3),and neutrophil-lymphocyte ratio(NLR)combined detection in evaluating the efficacy of interventional chemo-therapy for liver cancer patients.Method A total of 94 liver cancer patients who underwent interventional chemotherapy were selected.One day before surgery and thirty days after surgery,all patients received enhanced CT scan,and AFP-L3,neutrophil count and lymphocyte count were detected.According to clinical efficacy,the patients were divided into effec-tive treatment group[complete response(CR)+partial response(PR)]and ineffective treatment group[stable disease(SD)+progressive disease(PD)],and the clinical data of the two groups were compared.Logistic regression model was used to analyze the factors influencing the clinical efficacy of interventional chemotherapy for liver cancer patients.The receiver operating characteristic(ROC)curve was plotted,the area under the curve(AUC)was calculated,and the value of AEF,AFP-L3 and NLR single and combined detection in evaluating the efficacy of interventional chemotherapy for liver cancer patients were analyzed.Result Among 94 liver cancer patients,37 cases were in the effective treatment group(10 cases of CR,27 cases of PR)and 57 cases were in the ineffective treatment group(34 cases of SD,23 cases of PD).The proportion of patients with tumor diameter<5 cm,single tumor and TNM stage Ⅱb in the effective treatment group were higher than those in the ineffective treatment group,and the differences were statistically significant(P<0.05).The AEF,AFP-L3 and NLR at 30 days after surgery in the effective treatment group were significantly lower than those in the ineffective treatment group,and the differences were statistically significant(P<0.01).Multivariate Logistic re-gression analysis showed that higher AEF,AFP-L3 and NLR at 30 days after surgery were independent risk factors for the efficacy of interventional chemotherapy in liver cancer patients(P<0.05).ROC curve showed that the AUC of AEF,AFP-L3 and NLR combined detection in evaluating the efficacy of interventional chemotherapy for liver cancer patients was 0.963,and the sensitivity was 92.98%,which were higher than those of single detection.Conclusion Higher AEF,AFP-L3 and NLR at 30 days after surgery are independent risk factors for the efficacy of interventional chemotherapy in liver cancer patients.The combined detection of the three indicators can effectively evaluate the efficacy of interventional chemotherapy for liver cancer patients,and provide reference for follow-up treatment.
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