Application of continuous blood purification therapy in patients with malignant tumor complicated with acute kidney injury
Objective To investigate the application effect of continuous blood purification(CBP)in the treatment of patients with malignant tumors complicated with acute kidney injury(AKI).Method A total of 100 patients with malig-nant tumor complicated with AKI were divided into intermittent hemodialysis(IHD)group(n=44)and CBP group(n=56)according to different treatment methods.Clinical efficacy,renal function indexes[creatinine(Cr),cystatin C(Cyc-C),glomerular filtration rate(GFR)],hemodynamic indexes[cardiac output(CO),mean arterial pressure(MAP),heart rate(HR)],inflammatory factors[interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)]and health sta-tus[acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)]were compared between the two groups.Result The treatment effective rate of CBP group was higher than that of IHD group,the difference was statistically significant(P＜0.05).After treatment,the levels of Cr and Cyc-C decreased and GFR increased in both groups,the levels of Cr and Cyc-C in CBP group were lower than those in IHD group,and GFR was higher than that in IHD group,the differences were statistically significant(P＜0.05).After treatment,CO and MAP decreased and HR increased in both groups,CO and MAP in CBP group were lower than those in IHD group,and HR was higher than that in IHD group,the differences were statistically significant(P＜0.05).After treatment,the levels of IL-6,IL-1β and TNF-α in two groups decreased,and the levels of IL-6,IL-1β and TNF-α in CBP group were lower than those in IHD group,the differences were statistically sig-nificant(P＜0.05).At the completion of treatment and 14 days after the completion of treatment,the APACHEⅡ scores of two groups were lower than those before treatment,and the APACHEⅡ scores in CBP group were lower than those in IHD group,the differences were statistically significant(P＜0.05).Conclusion The CBP in the treatment of patients with malignant tumors with AKI can effectively improve the therapeutic effect,improve renal function,stabilize hemodynamic indexes,reduce the level of inflammatory factors,promote the rehabilitation of patients,and improve the prognosis of pa tients.
万方数据
维普
