Objective To investigate the expression and clinical significance of neuroepithelial cell transforming 1(NET1)in renal cell carcinoma(RCC).Method A total of 60 cases of RCC tissue,60 cases of paracancer tissue and 20 cases of normal kidney tissue were collected.The expression of NET1 in each tissue was detected by immunohistochemi-cal method,and the correlation between the expression of NET1 and clinical characteristics of RCC patients were ana-lyzed.Result The positive expression rate of NET1 in RCC tissues was significantly higher than those in paracancer tis-sues and normal kidney tissues,and the differences were statistically significant(P＜0.01).There were statistically signifi-cant differences in the expressions of NET1 in RCC tissues of RCC patients with different clinical stages,degrees of dif-ferentiation,lymph node metastasis and distant metastasis(P＜0.05).The positive expression of NET1 in RCC tissues was positively correlated with clinical stage,lymph node metastasis and distant metastasis,and negatively correlated with dif-ferentiation degree(P＜0.01).Conclusion The positive expression rate of NET1 in RCC tissues is high,and its positive expression is related to the differentiation degree,lymph node metastasis,distant metastasis and clinical stage of RCC pa-tients.
维普
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