Expression of tumor specific growth factor,alkaline phosphatase and α-fetal protein in breast cancer and their predictive value for postoperative recurrence
Objective To investigate the expression of tumor specific growth factor(TSGF),alkaline phosphatase(ALP)and α-fetal protein(AFP)in breast cancer and their predictive value for postoperative recurrence.Method A total of 120 patients with breast cancer were followed up for 6 months,and were divided into recurrence group(18 cases)and non-recurrence group(102 cases)according to postoperative recurrence.Serum TSGF,ALP and AFP levels were com-pared between the two groups.The influencing factors of postoperative recurrence of breast cancer were analyzed by Lo-gistic regression.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficacy of serum TSGF,ALP and AFP for postoperative recurrence of breast cancer.Result The serum TSGF,ALP and AFP levels in the recurrence group were significantly higher than those in the non-recurrence group,the differences were statistically signif-icant(P＜0.01).Logistic regression analysis showed that TSGF,ALP,AFP,clinical stage,lymph node metastasis and vas-cular invasion were influencing factors of postoperative recurrence of breast cancer(P＜0.05).The area under the curve(AUC)of combined detection of TSGF,ALP and AFP for predicting postoperative recurrence of breast cancer was 0.841,which was greater than that of TSGF,ALP and AFP alone detection(0.796,0.715 and 0.680).Conclusion Serum TSGF,ALP and AFP levels are elevated in postoperative recurrence patients with breast cancer,and the combined detection of TSGF,ALP and AFP has highly value in predicting postoperative recurrence of breast cancer.
breast cancertumor specific growth factoralkaline phosphataseα-fetal proteinrecurrence
万方数据
维普
