Effect of linaclotide combined with compound polyethylene glycol electrolytes powder on the quality of intestinal preparation before colonoscopy in patients undergoing laparoscopic colorectal cancer radical surgery
Objective To explore the effect of linaclotide combined with compound polyethylene glycol electrolytes powder(SF-PEG)on the quality of bowel preparation before colonoscopy in patients undergoing laparoscopic natural ori-fice specimen extraction surgery(NOSES)colorectal cancer radical surgery.Method A total of 80 patients undergoing laparoscopic NOSES colorectal cancer radical surgery were divided into conventional group A(n=25,given 3 L of SF-PEG for bowel preparation),conventional group B(n=13,given 2 L of SF-PEG for bowel preparation),and combination group(n=42,given 2 L of SF-PEG combined with linaclotide for bowel preparation)based on the different drugs used for bowel preparation before colonoscopy.The quality of bowel preparation[Boston bowel preparation scale(BBPS)],intesti-nal bubble scores,colonoscopy time,positive lesion detection,completion of total colon examination,tolerance of bowel preparation,and incidence of adverse reactions were compared among the three groups.Result The BBPS scores of the left colon,transverse colon,right colon and total score in the combined group were higher than those in the conventional group A and conventional group B,while the bubble score were lower than those in the conventional group A and conven-tional group B,the entry time,exit time,and total time of colonoscopy were shorter than those in the conventional group A and conventional group B,the detection rate of positive lesions and the completion rate of whole colon examination were higher than those in the conventional group A and conventional group B,and the total tolerance rate of bowel prepa-ration were higher than those in the conventional group A and conventional group B,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in BBPS score and total score,bubble score,colo-noscopy time,positive lesion detection rate,completion rate of total colon examination,and total tolerance rate of bowel preparation between conventional group A and conventional group B(P＞0.05).There were no statistically significant dif-ferences in the incidence of adverse reactions in bowel preparation among the conventional group A,conventional group B,and combination group(P＞0.05).Conclusion The linaclotide combind with SF-PEG can improve the quality of bow-el preparation and intestinal bubble in patients undergoing laparoscopic NOSES colorectal cancer radical surgery,im-prove bowel preparation tolerance,and have higher safety.
万方数据
维普
