Objective To investigate the application effect of respiratory gating technique in lung cancer patients with liver metastasis undergoing radiotherapy.Method A total of 82 lung cancer patients with liver metastasis were di-vided into control group and observation group,with 41 cases in each group.The control group received conventional ra-diotherapy,and the observation group received radiotherapy using respiratory gating technique.The clinical efficacy,tar-get area volume[gross tumor volume(GTV),internal target volume(ITV),planning target volume(PTV)],tumor mark-ers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),cyto-keratin 19 fragment antigen 21-1(CY-FRA21-1)],liver function indexes[total bilirubin(TBIL),aspartate transaminase(AST),alanine transaminase(ALT)],and quality of life[World Health Organization quality of life assessment-brief(WHOQOL-BREF)]were compared be-tween the two groups.Result The disease control rate of observation group was higher than that of control group,and the difference was statistically significant(P＜0.05).The ITV and PTV in observation group were significantly lower than those in control group,and the differences were statistically significant(P＜0.01).After treatment,the CEA,CA125,CY-FRA21-1,TBIL,AST and ALT levels in both groups were lower than those before treatment,and the CEA,CA125,CY-FRA21-1,TBIL,AST and ALT levels in observation group were lower than those in control group,and the differences were statistically significant(P＜0.05).After treatment,the scores of all dimensions of WHOQOL-BREF in both groups were higher than those before treatment,and the scores of all dimensions of WHOQOL-BREF in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).Conclusion Respiratory gating technique in lung cancer patients with liver metastasis undergoing radiotherapy has a good application effect,which can improve the target delineation accuracy and radiotherapy efficacy,reduce the level of tumor markers,improve liver function indicators and quality of life.
lung cancerliver metastasisrespiratory gating techniqueradiotherapytarget volumetumor markerfunction indicatorquality of life
万方数据
维普
