摘要
目的 探讨呼吸门控技术在肺癌肝转移患者放疗中的应用效果.方法 采用随机数字表法将82例肺癌肝转移患者分为对照组和观察组,每组41例,对照组患者采取常规放疗,观察组患者采取呼吸门控技术进行放疗.比较两组患者的临床疗效、靶区体积[大体肿瘤靶区(GTV)、内靶区(ITV)、计划靶区(PTV)]、肿瘤标志物[癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)]、肝功能指标[总胆红素(TBIL)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)]及生活质量[世界卫生组织生活质量测定量表简表(WHOQOL-BREF)].结果 观察组患者的疾病控制率高于对照组,差异有统计学意义(P＜0.05).观察组患者的ITV、PTV均明显低于对照组,差异均有统计学意义(P＜0.01).治疗后,两组患者CEA、CA125、CYFRA21-1、TBIL、AST及ALT水平均低于本组治疗前,观察组患者CEA、CA125、CYFRA21-1、TBIL、AST及ALT水平均低于对照组,差异均有统计学意义(P＜0.05).治疗后,两组患者WHOQOL-BREF各维度评分均高于本组治疗前,观察组患者WHOQOL-BREF各维度评分均高于对照组,差异均有统计学意义(P＜0.05).结论 呼吸门控技术在肺癌肝转移患者放疗中的应用效果较好,可提高靶区勾画精准性和放疗疗效,降低肿瘤标志物水平,改善肝功能指标和生活质量.
Abstract
Objective To investigate the application effect of respiratory gating technique in lung cancer patients with liver metastasis undergoing radiotherapy.Method A total of 82 lung cancer patients with liver metastasis were di-vided into control group and observation group,with 41 cases in each group.The control group received conventional ra-diotherapy,and the observation group received radiotherapy using respiratory gating technique.The clinical efficacy,tar-get area volume[gross tumor volume(GTV),internal target volume(ITV),planning target volume(PTV)],tumor mark-ers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),cyto-keratin 19 fragment antigen 21-1(CY-FRA21-1)],liver function indexes[total bilirubin(TBIL),aspartate transaminase(AST),alanine transaminase(ALT)],and quality of life[World Health Organization quality of life assessment-brief(WHOQOL-BREF)]were compared be-tween the two groups.Result The disease control rate of observation group was higher than that of control group,and the difference was statistically significant(P＜0.05).The ITV and PTV in observation group were significantly lower than those in control group,and the differences were statistically significant(P＜0.01).After treatment,the CEA,CA125,CY-FRA21-1,TBIL,AST and ALT levels in both groups were lower than those before treatment,and the CEA,CA125,CY-FRA21-1,TBIL,AST and ALT levels in observation group were lower than those in control group,and the differences were statistically significant(P＜0.05).After treatment,the scores of all dimensions of WHOQOL-BREF in both groups were higher than those before treatment,and the scores of all dimensions of WHOQOL-BREF in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).Conclusion Respiratory gating technique in lung cancer patients with liver metastasis undergoing radiotherapy has a good application effect,which can improve the target delineation accuracy and radiotherapy efficacy,reduce the level of tumor markers,improve liver function indicators and quality of life.
基金项目
江西省卫生健康委科技计划项目(202212559)
维普
万方数据