125I放射性粒子植入治疗对老年非小细胞肺癌患者癌性疼痛的影响
Effect of 125 I radioactive particle implantation therapy on cancer pain in elderly patients with non-small cell lung cancer
李广 1刘勇 1郭贺贺 2石山领 1陈亚飞1
作者信息
- 1. 周口市中心医院 呼吸科,河南 周口 4660000
- 2. 周口市中心医院 血液科,河南 周口 4660000
- 折叠
摘要
目的 探讨 125I放射性粒子植入治疗对老年非小细胞肺癌患者癌性疼痛的影响.方法 将110例老年非小细胞肺癌患者根据治疗方式的不同分为化疗组(n=54)和粒子植入组(n=56).化疗组患者采取紫杉醇+顺铂化疗方案,粒子植入组患者在化疗组的基础上采取 125I放射性粒子植入治疗.比较两组患者的临床疗效、疼痛程度[视觉模拟评分法(VAS)]、衰弱情况[Fried衰弱表型量表(FFP)]、肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC]及不良反应发生情况.结果 粒子植入组患者总有效率高于化疗组,差异有统计学意义(P﹤0.05).治疗后,两组患者VAS、FFP评分均较治疗前降低,FVC、FEV1及FEV1/FVC均较治疗前升高,且粒子植入组患者VAS、FFP评分均低于化疗组,FVC、FEV1及FEV1/FVC均高于化疗组,差异均有统计学意义(P﹤0.05).两组患者不良反应总发生率比较,差异无统计学意义(P﹥0.05).结论 125I放射性粒子植入治疗老年非小细胞肺癌患者,可以扭转衰弱,抑制癌性疼痛,提高肺功能,且较为安全,疗效确切.
Abstract
Objective To investigate the effect of 125I radioactive particle implantation on cancer pain in elderly pa-tients with non-small cell lung cancer.Method A total of 110 elderly patients with non-small cell lung cancer were divid-ed into chemotherapy group(n=54)and particle implantation group(n=56).Patients in the chemotherapy group received paclitaxel+cisplatin chemotherapy regimen,and patients in the particle implantation group received 125I radioactive parti-cle implantation therapy based on the chemotherapy group.The clinical efficacy,pain degree[visual analogue scale(VAS)],frailty status[Fried frailty phenotype(FFP)],pulmonary function indexes[forced vital capacity(FVC),forced ex-piratory volume in one second(FEV1),FEV1/FVC]and adverse reactions were compared between the two groups.Result The total effective rate in the particle implantation group was higher than that in the chemotherapy group,the difference was statistically significant(P<0.05).After treatment,the VAS and FFP scores in two groups were lower than those be-fore treatment,the FVC,FEV1 and FEV1/FVC were higher than those before treatment,and the VAS and FFP scores in particle implantation group were lower than those in chemotherapy group,the FVC,FEV1 and FEV1/FVC were higher than those in chemotherapy group,the differences were statistically significant(P<0.05).There was no significant differ-ence in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion 125I radioactive particle im-plantation in the treatment of elderly patients with non-small cell lung cancer can reverse frailty,inhibit cancer pain and improve lung function,and is relatively safe and effective.
关键词
非小细胞肺癌/癌性疼痛/125I放射性粒子植入/肺功能Key words
non-small cell lung cancer/cancer pain/125I radioactive particle implantation/lung function引用本文复制引用
基金项目
周口市中心医院2021年医学科技攻关计划立项项目(20210106)
出版年
2024
NETL
NSTL
万方数据