Diagnostic value of cystatin C,α1-microglobulin,and urinary microalbumin single and combined detection in multiple myeloma with renal injury
Objective To investigate the diagnostic value of cystatin C(Cys-C),α1-microglobulin(α1-MG),and uri-nary microalbumin(UMA)single and combined detection in multiple myeloma(MM)with renal injury.Method A total of 113 MM patients were selected and divided into injury group(n=36)and non-injury group(n=77)based on renal injury status.The levels of Cys-C,α1-MG,and UMA were compared between the two groups and different types of MM patients combined with renal injury.The receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,and the Cys-C,α1-MG,and UMA single and combined detection in diagnosing MM combined with renal injury were evaluated.Result The Cys-C,α1-MG,and UMA levels in the non-injury group were significantly lower than those in the injury group,and the differences were statistically significant(P＜0.01).The Cys-C,α1-MG,and UMA levels in MM patients with renal failure type were significantly higher than those in nephrotic syndrome type pa-tients,and the differences were statistically significant(P＜0.01).The AUC of Cys-C,α1-MG,and UMA combined detec-tion in diagnosing MM combined with renal injury was 0.804(95％CI:0.733-0.876),the sensitivity was 0.889,and the specificity was 0.909,all of which were higher than those of single detection.Conclusion The Cys-C,α1-MG,and UMA levels are high in MM patients combined with renal injury,and the combined detection of the three has higher value in di-agnosing MM combined with renal injury.
cystatin Cα1-microglobulinurinary microalbuminmultiple myelomarenal injurydiagnostic value
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