Objective To investigate the diagnostic value of combined detection of pepsinogen Ⅰ(PGI),gastrin-17(G-17)and carbohydrate antigen 72-4(CA72-4)in gastric cancer.Method A total of 40 patients with gastric cancer were selected as observation group and 38 patients with benign gastric diseases were selected as control group.The clinical characteristics of the two groups were compared,and the influencing factors of gastric cancer were analyzed.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of PGⅠ,G-17 and CA72-4 alone and combined detection in gastric cancer.Result The levels of serum G-17 and CA72-4 in observation group were significantly higher than those in control group,and the level of PGⅠ was significantly lower than that in control group,the differences were statistically significant(P＜0.01).Logistic regression analysis showed that G-17 and CA72-4 levels were risk factors for gastric cancer,and PGⅠ level was a protective factor for gastric cancer.ROC curve showed that the area under the curve(AUC)of serum PGⅠ,G-17 and CA72-4 in the diagnosis of gastric cancer were all greater than 0.70,and the combined detection had the highest diagnostic value.Conclusion The combined detec-tion of serum PGⅠ,G-17 and CA72-4 has higher sensitivity and specificity in the diagnosis of gastric cancer,and has high diagnostic value.When the serum G-17 and CA72-4 are highly expressed and the serum PGⅠ is low,it indicates high risk of gastric cancer.
关键词
胃癌/胃蛋白酶原Ⅰ/糖类抗原72-4/胃泌素-17/诊断价值
Key words
gastric cancer/pepsinogen Ⅰ/carbohydrate antigen 72-4/gastrin-17/diagnostic value
维普
万方数据