摘要
目的 探讨芪珍胶囊联合长春瑞滨+顺铂(NP)方案化疗对气虚血瘀兼瘀阻化热型非小细胞肺癌(NSCLC)患者的治疗效果.方法 根据治疗方法的不同将82例气虚血瘀兼瘀阻化热型NSCLC患者分为对照组(n=41,NP方案化疗)和观察组(n=41,芪珍胶囊联合NP方案化疗).比较观察组和对照组、不同病理类型及临床分期观察组患者的临床疗效.比较两组患者的生活质量和体重改善情况、气虚血瘀兼瘀阻化热症状改善情况、血常规指标[红细胞(RBC)、白细胞(WBC)、血小板计数(PLT)、血红蛋白(Hb)]及免疫功能指标(CD3+、CD4+、CD8+水平及CD4+/CD8+).结果 观察组患者的总有效率明显高于对照组,差异有统计学意义(P＜0.01).观察组中,鳞状细胞癌、腺癌、腺鳞癌患者的总有效率比较,差异无统计学意义(P＞0.05).观察组中,Ⅰ、Ⅱ、Ⅲ、Ⅳ期NSCLC患者的总有效率比较,差异有统计学意义(P＜0.05).治疗后,观察组患者的生活质量改善率明显高于对照组(P＜0.01),两组患者体重改善率比较,差异无统计学意义(P＞0.05).治疗后,观察组患者气虚血瘀兼瘀阻化热各症状改善率均高于对照组(P＜0.05).治疗后,观察组患者WBC、PLT、CD3+、CD4+水平及CD4+/CD8+均高于对照组,CD8+水平低于对照组,差异均有统计学意义(P＜0.05).结论 芪珍胶囊联合NP方案化疗不仅可提高气虚血瘀兼瘀阻化热型NSCLC患者的临床疗效和生活质量,还可改善患者的症状、血常规指标及免疫功能.
Abstract
Objective To investigate the therapeutic effect of Qizhen capsule combined with vinorelbine+cisplatin(NP)chemotherapy regimen in non-small cell lung cancer(NSCLC)patients with Qi deficiency and blood stasis and sta-sis-converting-to-heat syndrome.Method A total of 82 NSCLC patients with Qi deficiency and blood stasis and stasis-converting-to-heat syndrome were divided into control group(n=41,NP regimen chemotherapy)and observation group(n=41,Qizhen capsule combined with NP regimen chemotherapy)according to different treatment methods.The clinical efficacy of observation group and control group,patients with different pathological types and clinical stages in observa-tion group were compared.The improvement of quality of life,body weight and symptoms of Qi deficiency and blood sta-sis and stasis-converting-to-heat syndrome,blood routine indexes[red blood cell(RBC),white blood cell(WBC),platelet(PLT),hemoglobin(Hb)]and immune function indexes(CD3+,CD4+,CD8+and CD4+/CD8+)were compared between the two groups.Result The total effective rate in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.01).In the observation group,there was no statistically signifi-cant difference in total effective rate of patients with squamous cell carcinoma,adenocarcinoma,and adenosquamous car-cinoma(P＞0.05).In the observation group,there was significantly difference in total effective rate of patients with stageⅠ,Ⅱ,Ⅲ,and Ⅳ NSCLC(P＜0.05).After treatment,the improvement rate of quality of life in observation group was sig-nificantly higher than that in control group(P＜0.01),and there was no significant difference in the weight improvement rate between the two groups(P＞0.05).After treatment,the improvement rates of symptoms of Qi deficiency and blood stasis and stasis-converting-to-heat symptoms in observation group were higher than those in control group(P＜0.05).Af-ter treatment,the levels of WBC,PLT,CD3+,CD4+,and CD4+/CD8+in observation group were higher than those in con-trol group,and the level of CD8+was lower than that in control group,and the differences were statistically significant(P＜0.05).Conclusion Qizhen capsule combined with NP chemotherapy regimen not only can improve the clinical efficacy and quality of life of NSCLC patients with Qi deficiency and blood stasis and stasis-converting-to-heat syndrome,but al-so can improve the symptoms,blood routine indexes and immune function of patients.
维普
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