Therapeutic effect of Qizhen capsule combined with NP chemotherapy regimen in non-small cell lung cancer patients with Qi deficiency and blood stasis and stasis-converting-to-heat syndrome
Objective To investigate the therapeutic effect of Qizhen capsule combined with vinorelbine+cisplatin(NP)chemotherapy regimen in non-small cell lung cancer(NSCLC)patients with Qi deficiency and blood stasis and sta-sis-converting-to-heat syndrome.Method A total of 82 NSCLC patients with Qi deficiency and blood stasis and stasis-converting-to-heat syndrome were divided into control group(n=41,NP regimen chemotherapy)and observation group(n=41,Qizhen capsule combined with NP regimen chemotherapy)according to different treatment methods.The clinical efficacy of observation group and control group,patients with different pathological types and clinical stages in observa-tion group were compared.The improvement of quality of life,body weight and symptoms of Qi deficiency and blood sta-sis and stasis-converting-to-heat syndrome,blood routine indexes[red blood cell(RBC),white blood cell(WBC),platelet(PLT),hemoglobin(Hb)]and immune function indexes(CD3+,CD4+,CD8+and CD4+/CD8+)were compared between the two groups.Result The total effective rate in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.01).In the observation group,there was no statistically signifi-cant difference in total effective rate of patients with squamous cell carcinoma,adenocarcinoma,and adenosquamous car-cinoma(P＞0.05).In the observation group,there was significantly difference in total effective rate of patients with stageⅠ,Ⅱ,Ⅲ,and Ⅳ NSCLC(P＜0.05).After treatment,the improvement rate of quality of life in observation group was sig-nificantly higher than that in control group(P＜0.01),and there was no significant difference in the weight improvement rate between the two groups(P＞0.05).After treatment,the improvement rates of symptoms of Qi deficiency and blood stasis and stasis-converting-to-heat symptoms in observation group were higher than those in control group(P＜0.05).Af-ter treatment,the levels of WBC,PLT,CD3+,CD4+,and CD4+/CD8+in observation group were higher than those in con-trol group,and the level of CD8+was lower than that in control group,and the differences were statistically significant(P＜0.05).Conclusion Qizhen capsule combined with NP chemotherapy regimen not only can improve the clinical efficacy and quality of life of NSCLC patients with Qi deficiency and blood stasis and stasis-converting-to-heat syndrome,but al-so can improve the symptoms,blood routine indexes and immune function of patients.
Qizhen capsuleQi deficiency and blood stasisstasis-converting-to-heatnon-small cell lung cancerchemotherapyefficacy
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维普
