Objective To investigate the clinical efficacy of oxaliplatin combined with fluorouracil in the treatment of elderly patients with advanced gastric cancer.Method A total of 102 elderly patients with advanced gastric cancer were divided into irinotecan group(n=47)and oxaliplatin group(n=55)based on different treatment methods.Patients in the irinotecan group received irinotecan+fluorouracil treatment,while patients in the oxaliplatin group received oxaliplat-in+fluorouracil treatment.The clinical efficacy,quality of life[European Organization for Research and Treatment of Cancer quality of life questionnaire core 30(EORTC QLQ-C30)],and incidence of adverse reactions were compared be-tween two groups.Result The total effective rate in the oxaliplatin group was 41.82％,which was not significantly dif-ferent with 38.30％in the irinotecan group(P＞0.05).After treatment,the scores of all dimensions of EORTC QLQ-C30 in both groups were higher than those before treatment,and the scores of all dimensions of EORTC QLQ-C30 in the oxali-platin group were higher than those in the irinotecan group,the differences were statistically significant(P＜0.05).There were no statistically significant differences in the incidence of anemia,thrombocytopenia,liver dysfunction,stomatitis,nausea and vomiting,and hand foot syndrome between the two groups(P＞0.05).The incidence of leukopenia,diarrhea,and peripheral neurotoxicity in the oxaliplatin group were lower than those in the irinotecan group,and the differences were statistically significant(P＜0.05).Conclusion The clinical efficacy of oxaliplatin+fluorouracil and irinotecan+flu-orouracil chemotherapy regimens in the treatment of elderly patients with advanced gastric cancer are similar,but the for-mer has lower incidence of leukopenia,diarrhea,and peripheral neurotoxicity,and better quality of life for patients.
万方数据
维普
