Objective To explore the relationship between serum levels of vascular endothelial growth factor(VEGF),tumor markers[carcinoembryonic antigen(CEA),neuron specific enolase(NSE),squamous cell carcinoma anti-gen(SCC-Ag),cyto-keratin 19 fragment antigen 21-1(CYFRA21-1)]and clinical staging of lung cancer.Method A to-tal of 112 lung cancer patients were selected as the observation group,and 87 healthy individuals were selected as the con-trol group.The serum levels of VEGF,CEA,NSE,SCC-Ag,and CYFRA21-1 were compared between the two groups of subjects and lung cancer patients with different clinical stages.Correlation analysis was conducted by Spearman analysis;the receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,and the val-ue of VEGF,CEA,NSE,SCC-Ag,and CYFRA21-1 single and combined detection in diagnosing clinical staging of lung cancer were evaluated.Result The serum levels of VEGF,CEA,NSE,SCC-Ag,and CYFRA21-1 in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.01).The serum levels of VEGF,CEA,NSE,SCC-Ag,and CYFRA21-1 in stage Ⅲ-Ⅳ of lung cancer patients were significant-ly higher than those in stage Ⅰ-Ⅱ,and the differences were statistically significant(P＜0.01).The ROC curve showed that the AUC of VEGF,CEA,NSE,SCC-Ag,and CYFRA21-1 combined detection in diagnosing clinical staging of lung can-cer was 0.952(95％CI:0.915-0.989),which was higher than those of single detection of each indicator.At this time,the sensitivity was 0.862 and the specificity was 0.926.Serum VEGF,CEA,NSE,SCC-Ag,CYFRA21-1 were positively cor-related with the clinical staging of lung cancer patients(P＜0.05).Conclusion The levels of serum VEGF,CEA,NSE,SCC-Ag,and CYFRA21-1 in lung cancer patients are significantly elevated.These indicators combined detection has high diagnostic value for the clinical staging of lung cancer patients,and these indicators are positively correlated with clinical staging.
vascular endothelial growth factorcarcinoembryonic antigenneuron specific enolasesquamous cell carcinoma antigencyto-keratin 19 fragment antigen 21-1lung cancer
万方数据
维普
