Effect of modified ovarian transposition on sex hormone and tumor marker levels in patients with advanced cervical cancer
Objective To explore the effect of modified ovarian transposition on sex hormone and tumor marker lev-els in patients with advanced cervical cancer.Method A total of 166 patients with advanced cervical cancer were divid-ed into control group(n=75,extraperitoneal ovarian transposition)and observation group(n=91,modified ovarian trans-position)according to different surgical methods.The surgery-related indexes,sex hormones[progesterone(P),estradiol(E2),follicle stimulating hormone(FSH),testosterone(T),luteinizing hormone(LH),prolactin(PRL)]levels,tumor mark-ers[carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC-Ag),carbohydrate antigen 50(CA50)]lev-els,and the incidence of complications were compared between the two groups.Result The intraoperative blood loss in the observation group was significantly less than that in the control group,and the operation time,postoperative first ex-haust time and hospital stay were significantly shorter than those in the control group,and the differences were statistical-ly significant(P<0.01).Before and after treatment,there were no significant differences in P,E2,FSH,T,LH and PRL lev-els between the two groups(P>0.05).After treatment,the CEA,SCC-Ag and CA50 levels in both groups were lower than those before treatment,and the CEA,SCC-Ag and CA50 levels in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Modified ovarian transposition can reduce the levels of tumor markers in the treatment of advanced cervical cancer pa-tients,stabilize the levels of sex hormones,promote the postoperative recovery,and reduce the incidence of complications.
万方数据
维普
