Objective To investigate the effect of preserved and unpreserved intercostal brachial nerve on patients un-dergoing modified radical mastectomy for breast cancer.Method A total of 152 breast cancer patients underwent modi-fied radical mastectomy were divided into resection group(n=71)and reservation group(n=81)according to different sur-gical methods.The intercostal brachial nerve was not preserved in the resection group during operation,and the intercos-tal brachial nerve was preserved in the preservation group during operation.The perioperative indexes,the incidence of upper limb sensory disorders,the activity of the affected upper limb,and the incidence of complications were compared between the two groups.Result There were no significant differences in operation time,intraoperative blood loss,num-ber of lymph node dissection,postoperative drainage tube removal time,postoperative hospital stay and total incidence of complications between the two groups(P>0.05).At 1 week after operation,The range of motion for abduction,extension and flexion on the affected upper limb side in two groups were lower than those before operation,the range of motion for abduction,extension and flexion on the affected upper limb side in preservation group were higher than those in resection group,and the differences were statistically significant(P<0.05).The total incidence of upper limb sensory disorders in reservation group was 9.88%,which was lower than 25.35% in resection group,and the difference was statistically signifi-cant(P<0.05).Conclusion Preserved and unpreserved intercostal brachial nerve have little effect on perioperative index-es and incidence of complication of breast cancer patients undergoing modified radical mastectomy,but preserved inter-costal brachial nerve has less effect on postoperative upper limb sensory function and greater range of motion on the af-fected upper limb side.