Efficacy of Tongguanteng injection in the treatment of ovarian cancer patients undergoing postoperative chemotherapy
Objective To investigate the efficacy of Tongguanteng injection in the treatment of of ovarian cancer pa-tients undergoing postoperative chemotherapy.Method A total of 80 patients with ovarian cancer were randomly divid-ed into Tongguanteng group(n=40)and control group(n=40).The two groups were treated with operation and postopera-tive chemotherapy for ovarian cancer,and the Tongguanteng group was treated with Tongguanteng injection.The effica-cy,tumor markers levels,cytokines levels and the occurrence of adverse reactions after chemotherapy were compared be-tween the two groups.Result The total effective rate of Tongguanteng group was higher than that of control group,the difference was statistically significant(P＜0.05).After treatment,the levels of carbohydrate antigen 125(CA125)and hu-man epididymis protein 4(HE4)in two groups were lower than those before treatment,and the levels of CA125 and HE4 in Tongguanteng group were lower than those in control group,the differences were statistically significant(P＜0.05).Af-ter treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in Tongguanteng group were lower than those before treatment,while the levels of IL-6 and IL-8 in control group were lower than those be-fore treatment,and the levels of TNF-α,IL-6 and IL-8 in Tongguanteng group were lower than those in control group,the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in Tongguanteng group was lower than that in control group,and the difference was statistically significant(P＜0.05).Conclusion Tongguanteng in-jection can effectively improve the efficacy of postoperative chemotherapy in patients with ovarian cancer,reduce the lev-els of tumor markers and cytokines,and reduce the adverse reaction of postoperative chemotherapy,so it can be widely used in clinical practice.
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