Effect of sevoflurane inhalation at different concentrations on hemodynamics and stress response indexes in patients undergoing laparoscopic radical resection for gallbladder cancer
Objective To explore the effect of sevoflurane inhalation at different concentrations on hemodynamics and stress response indexes in patients undergoing laparoscopic radical resection for gallbladder cancer.Method Accord-ing to the concentration of sevoflurane inhalation during anesthesia,60 patients undergoing laparoscopic radical resection for gallbladder cancer were divided into low-dose group[n=21,0.5 minimum alveolar concentration(MAC)],medium-dose group(n=20,1.0MAC)and high-dose group(n=1 9,1.5MAC).The hemodynamic indexes[pulse oxygen saturation(SpO2),mean arterial pressure(MAP),heart rate(HR)],stress response indexes[epinephrine(E),norepinephrine(NE)]and the occurrence of adverse reactions were compared between the two groups.Result After induction of anesthesia,1 min and 10 min of tracheal intubation,the SpO2,MAP and HR in the three groups were lower than those before anesthe-sia,and the SpO2,MAP and HR in low-dose group and high-dose group were lower than those in medium-dose group,and the differences were statistically significant(P＜0.05).At 10 min after anesthesia induction,30 min after pneumoperi-toneum establishment,and 30 min after surgery,the E and NE levels in the three groups were lower than those 10 min be-fore anesthesia induction,and the E and NE levels in low-dose group and high-dose group were higher than those in medi-um-dose group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions among the three groups(P＞0.05).Conclusion 1.0MAC sevoflurane inhalation can main-tain hemodynamic stability and reduce stress response in patients undergoing laparoscopic radical resection for gallblad-der cancer,and has a certain safety.
sevofluranelaparoscopic radical resection for gallbladder cancerhemodynamicsstress response
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维普
