Objective To explore the risk factors and drug resistance of postoperative fungal infection in elderly pa-tients with gastrointestinal malignant tumors.Method According to the occurrence of postoperative fungal infection,83 elderly patients with gastrointestinal malignant tumors were divided into fungal infection group(n=47)and non-fungal in-fection group(n=36).The clinical characteristics of fungal infection group and non-fungal infection group were com-pared,and the risk factors of postoperative fungal infection in elderly patients with gastrointestinal malignant tumors were analyzed by Logistic regression model.Samples of patients with fungal infection were collected for culture,identifi-cation and drug sensitivity test,and the fungal distribution and antimicrobial resistance were analyzed.Result Univari-ate analysis showed that there were statistically significant differences in underlying diseases,recent anti-infection treat-ment,white blood cell count,clinical stage,rapid rehabilitation surgical treatment and operation time between fungal in-fection group and non-fungal infection group(P＜0.05).Multivariate Logistic regression analysis showed that combined underlying diseases,recent anti-infective therapy and white blood cell count＜4.0× 109/L were risk factors for postoperative fungal infection in elderly patients with gastrointestinal malignant tumors(P＜0.05).A total of 178 strains of fungi were detected in 47 patients with postoperative fungal infection,among which Candida albicans was the most common(122 strains,68.54％),followed by Candida glabra(25 strains,14.04％).The drug resistance rate of 178 strains to itraconazole was the highest(82.02％),followed by fluconazole(77.53％);the drug resistance rate to fluorocytosine was the lowest(5.62％),followed by amphotericin(6.18％).Conclusion Combined underlying diseases,recent anti-infective therapy and white blood cell count＜4.0× l09/L were risk factors for postoperative fungal infection in elderly patients with gastroin-testinal malignant tumors.Among the antifungal drugs,itraconazole and fluconazole had higher resistance rates,while amphotericin and fluorocytosine had lower resistance rates.
维普
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