Objective To investigate the relationship between the expression of programmed cell death 1 ligand 1(PD-L1)and the clinical features and prognosis of patients with renal cell carcinoma(RCC).Method The medical re-cords of 120 patients with RCC were collected,the expression of PD-L1 in RCC patients with different pathological types and clinical features were compared,the influencing factors of PD-L1 expression in RCC patients were analyzed by Cox regression model.All patients were followed up for one year,and the survival of RCC patients with different PD-L1 ex-pression was analyzed.Result Among 120 RCC patients,64 cases were positive for PD-L1 and 56 cases were negative,with a positive expression rate of 53.33％.There was no significant difference in the positive expression rate of PD-L1 among RCC patients with different pathological types(P＞0.05).The positive expression rates of PD-L1 in RCC patients with different ages and clinical stages were compared,and the differences were statistically significant(P＜0.05).Cox re-gression analysis showed that age＞60 years old and clinical stage Ⅲ-Ⅳ were risk factors for positive expression of PD-L1 in RCC patients(P＜0.05).The survival rate of RCC patients with PD-L1 negative expression was higher than that of patients with PD-L1 positive expression,and the difference was statistically significant(P＜0.05).Conclusion The ex-pression of PD-L1 is related to the age and clinical stage of RCC patients.The survival rate of RCC patients with PD-L1 positive expression is lower.Age＞60 years old and clinical stage Ⅲ-Ⅳ are risk factors for positive expression of PD-L1 in RCC patients.
renal cell carcinomaprogrammed cell death 1 ligand 1clinical featureprognosis
万方数据
维普
