Diagnostic value of ultrasound-guided fine-needle aspiration cytology,v-raf murine sarcoma viral oncogene homolog B V600E gene mutation single and combined detection for thyroid cancer
Objective To explore the diagnostic value of ultrasound-guided fine-needle aspiration(FNA)cytology,v-raf murine sarcoma viral oncogene homolog B(BRAF)V600E gene mutation single and combined detection for thyroid cancer.Method A total of 127 patients with thyroid nodules were selected and underwent ultrasound-guided FNA cytol-ogy and BRAF V600E gene mutation detection.Pathological examination result was used as the gold standard,the diag-nostic value of FNA cytology and BRAF V600E gene mutation single and combined detection for thyroid cancer were evaluated.The Kappa test was used to evaluate the consistency between the results of FNA cytology and BRAF V600E gene mutation single and combined detection for the diagnosis of thyroid cancer and the pathological examination results.Result The sensitivity of FNA cytology and BRAF V600E gene mutation combined detection for the diagnosis of thy-roid cancer was 98.06％,specificity was 100％,accuracy was 98.43％,positive predictive value was 100％,and negative predictive value was 92.31％,which were higher than those of the single detection.The consistency between the results of FNA cytology and BRAF V600E gene mutation combined detection in diagnosing thyroid cancer and pathological exami-nation was extremely high(Kappa=0.950),which was higher than those of BRAF V600E gene mutation detection(Kap-pa=0.877)and FNA cytology detection(Kappa=0.772),respectively.Pathological examination results showed that 103 cases were positive(thyroid cancer)and 24 cases were negative,which were classified as malignant group and benign group,respectively.The FNA cytology score of malignant group was significantly higher than that of benign group,and the CT value of BRAF V600E gene mutation detection was significantly lower than that of benign group,the differences were statistically significant(P＜0.01).Conclusion The FNA cytology and BRAF V600E gene mutation combined detec-tion has high diagnostic value for thyroid cancer.
万方数据
维普
