Application effect of systematic intervention based on Peplau's interpersonal relationship theory in lymphoma patients undergoing chimeric antigen receptor T cell therapy
Objective To investigate the application effect of systematic intervention based on Peplau's interpersonal relationship theory in lymphoma patients undergoing chimeric antigen receptor T cell therapy(CAR-T).Method A total of 135 lymphoma CAR-T therapy patients were divided into control group(n=68)and observation group(n=67)based on different intervention methods.The control group received routine intervention,while the observation group received sys-tematic intervention based on Peplau's interpersonal relationship theory.The fear level of disease[fear of progression questionnaire-short form(FoP-Q-SF)],quality of life[World Health Organization quality of life-brief(WHOQOL-BREF)]and satisfaction[Newcastle satisfaction with nursing scale(NSNS)]were compared between the two groups.Re-sult After intervention,the physiological health and social family scores of both groups were lower than those before in-tervention,the physiological health and social family scores of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).After intervention,the dimensional scores of WHOQOL-BREF in both groups were higher than those before intervention,the dimensional scores of WHOQOL-BREF in the ob-servation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The satisfaction in the observation group was 97.01％,which was higher than 85.29％in the control group,and the differ-ence was statistically significant(P＜0.05).Conclusion Systematic intervention based on Peplau's interpersonal relation-ship theory can effectively alleviate the fear of lymphoma CAR-T therapy patients towards the disease,improve quality of life,and enhance satisfaction.
lymphomachimeric antigen receptor T cell therapysystematic intervention based on Peplau's interper-sonal relationship theoryquality of life
万方数据
维普
