Predictive value of systemic immune inflammatory index combined with CD4+and CD8+for postoperative pulmonary infection in patients with lung cancer complicated with chronic obstructive pulmonary disease
Objective To investigate the predictive value of systemic immune inflammatory index(SII)combined with CD4+and CD8+for postoperative pulmonary infection in patients with lung cancer complicated with chronic obstruc-tive pulmonary disease(LC-COPD).Method A total of 96 patients with LC-COPD were divided into infected group(41 cases)and non-infected group(55 cases)according to whether postoperative pulmonary infection.The plasma neutrophil count(NEU),lymphocyte count(LYM),platelet count(PLT),CD4+and CD8+levels of the two groups were compared,and SII,CD4+/CD8+were calculated 1 day before surgery,1 day after surgery and 3 days after surgery.The correlation be-tween SII and CD4+,CD8+,CD4+/CD8+was analyzed.The predictive value of SII,CD4+,CD8+,CD4+/CD8+single and combined detection for postoperative pulmonary infection in patients with LC-COPD were analyzed by receiver operat-ing characteristic(ROC)curve.Result One day and three days after surgery,the levels of plasma NEU,PLT,CD8+and SII in infected group were higher than those in non-infected group,while the levels of plasma LYM,CD4+and CD4+/CD8+were lower than those in non-infected group,the differences were statistically significant(P＜0.05).In LC-COPD patients,SII was negatively correlated with CD4+,CD4+/CD8+,and positively correlated with CD8+(P＜0.01).ROC curve showed that the area under the curve(AUC)of combined detection of SII,CD4+,CD8+and CD4+/CD8+predicted postop-erative pulmonary infection in LC-COPD patients was 0.958(95％CI:0.925-0.992),which was higher than that of each indicator alone.Conclusion After postoperative pulmonary infection in patients with LC-COPD,the levels of plasma NEU,PLT,CD8+and SII increase,while the levels of plasma LYM,CD4+and CD4+/CD8+decrease.Postoperative dynam-ic detection of various indicators in patients with LC-COPD can predict postoperative pulmonary infection.
systemic immune inflammatory indexCD4+CD8+lung cancer complicated with chronic obstructive pulmonary diseasepostoperative infection
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