Expression levels of serum human epididymis protein 4,carcinoembryonic antigen,neuron specific enolase in patients with carbohydrate antigen 125 negative ovarian cancer and their relationship with prognosis
Objective To investigate the expression levels of serum human epididymis protein 4(HE4),carcinoem-bryonic antigen(CEA)and neuron specific enolase(NSE)in carbohydrate antigen 125(CA125)negative ovarian cancer patients and their relationship with prognosis.Method A total of 107 patients with CA125 negative ovarian cancer were selected as observation group and 81 patients with benign ovarian tumor were selected as control group.The expression levels of HE4,CEA and NSE were compared between the two groups.Multivariate Logistic regression model was used to analyze the prognostic factors of CA125 negative ovarian cancer patients.Result The levels of serum HE4,CEA and NSE in observation group were significantly higher than those in control group,the differences were statistically signifi-cant(P＜0.01).There were significant differences in differentiation degree,clinical stage and HE4,CEA,NSE levels be-tween patients with good prognosis and poor prognosis(P＜0.01).Multivariate Logistic regression analysis showed that high expression of HE4,CEA and NSE were risk factors for poor prognosis of CA125 negative ovarian cancer patients(P＜0.05).Conclusion Compared with benign ovarian tumor patients,HE4,CEA and NSE are highly expressed in CA125 negative ovarian cancer patients,and the expression levels of HE4,CEA and NSE can affect the prognosis of CA125 negative ovarian cancer patients.The lower the levels of the three indexes,the better the prognosis of ovarian can-cer patients.
ovarian cancerhuman epididymis protein 4carcinoembryonic antigenneuron specific enolasecarbo-hydrate antigen 125 negativeprognosis
万方数据
维普
