Objective To investigate the effects of esketamine(esk)on stress response,inflammation response and immune response in patients with abdominal radical hysterectomy(ARH)for cervical cancer.Method A total of 80 pa-tients with cervical cancer were divided into esk group(n=43)and reference group(n=37)according to whether esk was used.Stress response indexes[cortisol(Cor),blood glucose(Glu),adrenocorticotropic hormone(ACTH)],immune re-sponse indexes[CD4+,CD8+,CD3+,natural killer(NK)cell,CD4+/CD8+]and inflammatory response indicators[tumor ne-crosis factor-α(TNF-α),interleukin-8(IL-8),interleukin-1 β(IL-1β)]were compared between the two groups at different time points[before anesthesia induction(T0),awakening immediately after surgery(T1),1 day after surgery(T2),3 days af-ter surgery(T3)].Result During T0-T3 period,the levels of Cor,Glu,ACTH,TNF-α,IL-8 and IL-1 β in two groups were firstly increased and then decreased,and during T1-T3 period,the levels of Cor,Glu,ACTH,TNF-α,IL-8 and IL-1 β in esk group were lower than those in reference group,the differences were statistically significant(P＜0.05).During T0-T3 peri-od,the levels of CD3+,CD4+,NK cell and CD4+/CD8+in two groups were firstly decreased and then increased,and dur-ing T1-T3 period,the levels of CD3+,CD4+,NK cell and CD4+/CD8+in esk group were higher than those in reference group,the differences were statistically significant(P＜0.05).Conclusion The application of esk in cervical cancer pa-tients treated with ARH can effectively relieve stress response and inflammatory response,reduce the immune suppres-sion,and has the value of popularization and application.
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