Efficacy of intraperitoneal hyperthermic chemotherapy combined with intravenous chemotherapy and laparoscopic surgery in ovarian cancer patients and its effect on inflammatory microcirculation
Objective To investigate the efficacy of intraperitoneal hyperthermic chemotherapy combined with intra-venous chemotherapy and laparoscopic surgery in ovarian cancer patients and its effect on inflammatory microcirculation.Method A total of 170 patients with ovarian cancer were divided into conventional group(n=85,received intravenous chemotherapy combined with laparoscopic surgery)and combined group(n=85,received intraperitoneal hyperthermic chemotherapy combined with intravenous chemotherapy and laparoscopic surgery)according to different treatment meth-ods.The clinical efficacy,vascular endothelial growth factor(VEGF)level,T lymphocyte subsets levels,quality of life[Karnofsky performance status(KPS)score]and the incidences of adverse reactions were compared between the two groups.Result The total effective rate of the combined group was higher than that of the conventional group,the differ-ence was statistically significant(P<0.01).After treatment,the levels of VEGFA,VEGFB and VEGFC in combined group were significantly lower than those in conventional group,while the levels of CD3+,CD4+and CD4+/CD8+were sig-nificantly higher than those in conventional group,the differences were statistically significant(P<0.01).After treatment,the KPS score in combined group was significantly higher than that in conventional group,and the difference was statisti-cally significant(P<0.01).There were no significant differences in the incidences of abdominal pain,nausea and vomit-ing,bone marrow suppression and renal function injury between the two groups(P>0.05).Conclusion Intraperitoneal hyperthermic chemotherapy combined with intravenous chemotherapy and laparoscopic surgery is effective in the treat-ment of ovarian cancer patients,which can reduce VEGF level,regulate T lymphocyte subsets,and improve the quality of life.
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